ICSF
Identification of Conserved Structural Features
Identification of Conserved Structural Features (ICSF) is a Perl program that identifies conserved structural features at sequentially degenerate locations in transcription factor binding sites. ICSF uses base-pair step parameters obtained from a collection of high-resolution DNA crystal structures to discover structural conservation that exists in the sequentially degenerate areas within a binding site and produce profiles of the structural features along the entire site.