Gene Regulation Tools Protein Engineering Tools
 
Ghildiyal M., Seitz H., Horwich M.D., Li C., Du T., Lee S., Xu J., Kittler E.L., Zapp M.L., Weng Z., Zamore P.D. (2008)
Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells.
Science, In press
Abstract PDF
 
Weng Z., Guigo R. (2008)
In silico meets in vivo.
Genome Biol. 2008 Feb 25;9(2):302
Abstract PDF
 
Hwang H., Pierce B., Mintseris J., Janin J., Weng Z. (2008)
Protein-protein docking benchmark version 3.0.
Proteins, In Press
 
Zhang X., Guo C., Chen Y., Shulha H. P., Schnetz M. P., LaFramboise T., Bartels C. F., Markowitz S., Weng Z., Scacheri P. C., Wang Z. (2008)
Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies.
Nat Methods. 5(2):163-5.
Abstract PDF
 
Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, Kapranov P, Nix DA, Gingeras TR, Zhang X, Holster H, Jiang N11, Green R, Song JS, McCuine SA, Anton E, Nguyen L, Trinklein ND, Ye Z, Ching K, Hawkins D, Ren B, Scacheri PC, Rozowsky J, Karpikov A, Euskirchen G, Weissman S, Gerstein M, Snyder M, Yang A, Moqtaderi Z, Hirsch H, Shulha HP, Fu Y, Weng Z, Struhl K, Myers RM, Lieb JS, and Liu XS (2008)
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.
Genome Research, 18, 393-403.
Abstract PDF
 
Pierce B, Weng Z (2008)
A combination of rescoring and refinement significantly improves protein docking performance.
Proteins, 72(1):270-279
Abstract PDF
 
Wiehe K, Peterson MW, Pierce B, Mintseris J, Weng Z (2007)
Protein-protein docking: overview and performance analysis
Methods Mol Biol 413, 283-314.
Abstract PDF
 
Wiehe K, Pierce B, Tong W, Hwang H, Mintseris J, Weng Z (2007)
The Performance of ZDOCK and ZRANK in Rounds 6-11 of CAPRI
Proteins 69(4), 719-725.
Abstract PDF
 
Peckham HE, Thurman RE, Fu Y, Stamatoyannopoulos JA, Noble WS, Struhl K, Weng Z(2007)
Nucleosome Positioning Signals in Genomic DNA.
Genome Research, 17, 1170-1177.
Abstract PDF
 
Mintseris J, Pierce B, Wiehe K, Anderson R, Chen R, and Weng Z (2007)
Integrating Statistical Pair Potentials into Protein Complex Prediction.
Proteins, 69(3), 511-520.
Abstract PDF
 
Xi H., Shulha H.P., Lin J.M., Vales T.R., Fu Y., Bodine D.M., McKay R.D.J,
Chenoweth J.G., Tesar P.J., Furey T.S., Ren B., Weng Z.
+, Crawford G.E.+ (2007)
Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.
+Co-corresponding authors
PLoS Genetics, 8, 8-20.
Abstract PDF

The ENCODE Consortium (2007)
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
Nature 447, 799-816.
Weng Z. was as a co-chair for the ENCODE Transcriptional Regulation analysis group and a co-corresponding author of this Nature article.
Abstract PDF

Trinklein ND*, Karaoz U*, Wu J*, Halees A*, Aldred SF, Collin PJ, Zheng D, Zhang ZD, Gerstein M, Snyder M, Myers RM+, Weng Z+ (2007)
Integrated analysis of experimental datasets reveals many novel promoters in 1% of the human genome.
*Authors contributed equally
+Co-corresponding authors
Genome Research 17, 720-731.
Abstract PDF

Christoph M. Koch, Robert M. Andrews, Paul Flicek, Shane C. Dillon, Ulas Karaoz, Gayle K. Clelland, Sarah Wilcox, David M. Beare, Joanna C. Fowler, Phillippe Couttet, Keith D. James, Gregory C. Lefebvre, Alexander W. Bruce, Oliver M. Dovey, Peter D. Ellis, Pawandeep Dhami, Cordelia F. Langford, Zhiping Weng, Ewan Birney, Nigel P. Carter, David Vetrie, and Ian Dunham (2007)
The landscape of histone modifications across 1% of the human genome in five human cell lines.
Genome Research 17, 691-707.
Abstract PDF

Zhang ZD, Paccanaro A, Fu Y, Weissman S, Weng Z, Chang J, Snyder M, Gerstein MB (2007)
Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions.
Genome Research 17, 787-97.
Abstract PDF

Heintzman ND, Stuart RK, Hon G, Fu Y, Ching CW, Hawkins RD, Barrera LO, Van Calcar S, Qu C, Ching KA, Wang W, Weng Z, Green RD, Crawford GE, Ren B (2007)
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.
Nature Genetics, 39(3):311-8.
Abstract PDF

Xi H, Yu Y, Foley J, Halees A, Weng Z (2007)
Analysis of Overrepresented Motifs in Human Core Promoters Reveals Dual Regulatory Roles of YY1.
Genome Research 17, 798-806.
Abstract PDF
 
Lin J, Collins PJ, Trinklein ND, Fu Y, Xi H, Myers RM, Weng Z (2007)
Transcription Factor Binding and Modified Histones in Human Bidirectional Promoters.
Genome Research 17, 818-827.
Abstract PDF
 
Pierce B, Weng Z (2007)
ZRANK: Reranking Protein Docking Predictions with an Optimized Energy Function.
Proteins 67(4): 1078-1086.
Abstract PDF
 
Pierce B, Phillips AT, Weng Z (2007)
Structure Prediction of Protein Complexes.
In Xu Y, Xu D & Liang J. (Eds.), Computational Methods for Protein Structure Prediction and Modeling Volume 2: Structure Prediction. (pp. 109-134). New York: Springer.
PDF
 
Zeller KI, Zhao XD, Lee CWH, Chiu KP, Yao F, Yustein JT, Ooi HS, Orlov YL, Shahab A, Yong HC, Fu Y, Weng Z, Kuznetsov VA, Sung WK, Ruan Y, Dang CV, Wei CL (2006)
Global mapping of c-Myc binding sites and target gene networks in human B cells.
PNAS 103(47): 17834–17839.
Abstract PDF
 
Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao XD, Chew JL, Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y (2006)
A Global Map of p53 Transcription Factor Binding Sites in the Human Genome.
Cell 124(1): 207-219.
Abstract PDF
 
Fu Y, Weng Z (2005)
Improvement of TRANSFAC matrices using multiple local alignment of transcription factor binding site sequences.
Genome Inform Ser Workshop Genome Inform. 16(1):68-72.
Abstract PDF
 
Burden HE, Weng Z (2005)
Identification of conserved structural features at sequentially degenerate locations in transcription factor binding sites.
Genome Inform Ser Workshop Genome Inform. 16(1):49-58.
Abstract PDF
 
Yu L*, Haverty PM*, Mariani J, Wang Y, Shen HY, Schwarzschild MA, Weng Z, Chen JF (2005)
Genetic and Pharmacological Inactivation of Adenosine A2A Receptor Reveals an Egr-2 Mediated Transcriptional Regulatory Network in the Mouse Striatum.
Physiological Genomics 23(1), 89-102. *Authors contributed equally.
Abstract PDF
 
Leyfer D, Weng Z (2005)
Genome-wide decoding of hierarchical modular structure of transcriptional regulation by cis-element and expression clustering.
Bioinformatics 21(Supplement 2), ii197-ii203.
Abstract PDF
 
Peters B, Bui HH, Sidney J, Weng Z, Loffredo JT, Watkins DI, Mothe BR, Sette A (2005)
A computational resource for the prediction of peptide binding to Indian rhesus macaque MHC class I molecules.
Vaccine 23(45), 5212-5224.
Abstract PDF
 
Szustakowski JD, Kasif S, Weng Z (2005)
Less is more: towards an optimal universal description of protein folds
Bioinformatics 21(Supplement 2), ii66-ii71.
Abstract PDF
 
Anderson RJ, Weng Z, Campbell RK, Jiang X (2005)
Main-chain conformational tendencies of amino acids
Proteins 60(4), 679-689.
Abstract PDF
 
Mintseris J, Weng Z (2005)
Structure, function, and evolution of transient and obligate protein-protein interactions
PNAS 102(31), 10930-10935.
Abstract PDF Dataset
 
Mintseris J, Wiehe K, Pierce B, Anderson R, Chen R, Janin J, Weng Z (2005)
Protein-Protein Docking Benchmark 2.0: an update
Proteins 60(2), 214-216.
Abstract PDF
 
Wiehe K, Pierce B, Mintseris J, Tong W, Anderson R, Chen R, Weng Z (2005)
ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5
Proteins 60(2), 207-213.
Abstract PDF
 
Pierce B, Tong W, Weng Z (2005)
M-ZDOCK: A Grid-based Approach for Cn Symmetric Multimer Docking
Bioinformatics 21(8), 1472-1476.
Abstract PDF
 
Haverty PM, Weng Z, Hansen U (2005)
Transcriptional Regulatory Networks Activated by PI3K and ERK Transduced Growth Signals in Human Glioblastoma Cells
J. Comput. Sci. & Tech. 20(4), 439-445.
PDF
 
Yanai I*, Yu Y*, Zhu X, Cantor C, Weng Z (2005)
*Joint First Authors
An Avidin-like Domain that Does Not Bind Biotin Is Adopted for Oligomerization by the Extracellular Mosaic Protein Fibropellin
Protein Science, Vol 14, 417-423.
Abstract PDF
 
Zhu J, Weng Z (2005)
FAST: A Novel Protein Structure Alignment Algorithm
Proteins: Structure Function, and Bioinformatics, Vol 58, 618-627.
Abstract PDF
 
Tompa M, Li N, Bailey TL, Church GM, De Moor B, Eskin E, Favorov AV, Frith MC, Fu Y, Kent WJ, Makeev VJ, Mironov AA, Noble WS, Pavesi G, Pesole G, Regnier M, Simonis N, Sinha S, Thijs G, van Helden J, Vandenbogaert M, Weng Z, Workman C, Ye C, Zhu Z. (2005)
Assessing computational tools for the discovery of transcription factor binding sites.
Nature Biotechnology, Vol 23, 137-144.
Abstract PDF
 
The ENCODE Project Consortium (2004)
The ENCODE (ENCyclopedia Of DNA Elements) Project
Science, Vol 306, 636-640.
Abstract PDF
 
Haverty PM, Hsiao L, Gullans SR, Hansen U, Weng Z (2004)
Limited Agreement among Three Global Gene Expression Methods Highlights the Requirement for Non-Global Validation
Bioinformatics. Vol 20, 3431-3441.
Abstract PDF
 
Hu Z, Fu Y, Halees AS, Kielbasa SM, Weng Z (2004)
SeqVISTA: a New Module of Integrated Computational Tools for Studying Transcriptional Regulation
Nucleic Acids Res., Vol 32, Web Server Issue, W235-W241.
Abstract PDF
 
Mintseris J, Weng Z (2004)
Optimizing Protein Representations with Information Theory
Genome Informatics, 15(1):160-169
Abstract PDF
 
Halees AS, Weng Z (2004)
PromoSer: Improvements on Algorithm, Visualization and Accessibility
Nucleic Acids Res., Vol 32, Web Server Issue, W191-W194.
Abstract PDF
 
Fu, Y., Frith, M.C., Haverty, P.M. & Weng, Z. (2004)
MotifViz: an Analysis and Visualization Tool for Motif Discovery
Nucleic Acids Res., Vol. 32, Web Server Issue, W420-W423.
Abstract PDF
 
Haverty, P.M., Frith, M.C. & Weng, Z. (2004)
CARRIE Web Service: Automated Transcriptional Regulatory Network Inference and Interactive Analysis
Nucleic Acids Res., Vol. 32, Web Server Issue, W213-W216.
Abstract PDF
 
Leyfer, D., Bond, A., Tworog, E., Perron, D., Maska, S., Brito, A., Kamens, J., Weng, Z. & Voss, J. (2004)
Cis-Element Clustering Correlates with Dose-Dependent Pro- and Anti- Signaling Effects of IL18
Genes and Immunity, June 10, 1-9
Abstract PDF
 
Haverty, P.M. & Weng, Z. (2004)
CisML, an XML-based Format for Sequence Motif Detection Software
Bioinformatics, 20(11), 1815-1817.
Abstract PDF
 
Frith, M. C., Fu, Y., Yu, L., Chen, J. F., Hansen, U. & Weng, Z. (2004)
Detection of Functional DNA Motifs via Statistical Overrepresentation
Nucleic Acids Res. 2004 Feb 26; 32(4):1372-1381.
Abstract PDF
 
Frith, M. C.*, Halees, A. S.*, Hansen, U. & Weng, Z. (2004)
*Joint First Authors
Site2genome: Locating Short DNA Sequences in Whole Genomes
Bioinformatics. 20(9):1468-1469
Abstract PDF
 
Haverty, P. M., Hansen, U. & Weng, Z. (2004)
Computational Inference of Transcriptional Regulatory Networks from Expression Profiling and Transcription Factor Binding Site Identification
Nucleic Acids Res. 2004 Jan 1;32(1):179-188.
Abstract PDF
 
Frith, M. C., Hansen, U., Spouge, J. L. & Weng, Z. (2004)
Finding Functional Sequence Elements by Multiple Local Alignment
Nucleic Acids Res. 2004 Jan 1;32(1):189-200.
Abstract PDF
 
Peters, B., Tong, W., Sidney, J., Sette, A. & Weng, Z. (2003)
Examining the Independent Binding Assumption for Binding of Peptide Epitopes to MHC-I Molecules
Bioinformatics. 19:1765-1772.
Abstract PDF
 
Halees, A.S., Leyfer, D. & Weng, Z. (2003)
PromoSer: A Larger-scale Mammalian Promoter and Transcription Start Site Identification Service.
Nucleic Acids Res. 2003 Jul 1;31(13):3554-9.
Abstract PDF
 
Frith, M.C., Li, M.C. & Weng, Z. (2003)
Cluster-Buster: Finding Dense Clusters of Motifs in DNA Sequences.
Nucleic Acids Res. 2003 Jul 1;31(13):3666-8.
Abstract PDF
 
Li, L.*, Chen, R.* & Weng, Z. (2003)
*Joint First Authors
RDOCK: Refinement of Rigid-body Protein Docking Predictions.
Proteins. 53:693-707.
Abstract PDF
 
Mintseris, J. & Weng, Z. (2003)
Atomic Contact Vectors in Protein-Protein Recognition.
Proteins. 53:629-639.
Abstract PDF
 
Chen, R., Tong, W., Mintseris, J., Li, L. & Weng, Z. (2003)
ZDOCK Predictions for the CAPRI Challenge.
Proteins. 2003 Jul 1;52(1):68-73.
Abstract PDF
 
Chen, R., Li, L. & Weng, Z. (2003)
ZDOCK: An Initial-stage Protein Docking Algorithm.
Proteins. 2003 Jul 1;52(1):80-7.
Abstract PDF
 
Chen, R., Mintseris, J., Janin, J. & Weng, Z. (2003)
A Protein-Protein Docking Benchmark.
Proteins. 2003 Jul 1;52(1):88-91
Abstract PDF
 
Chen, R. & Weng, Z. (2003)
A Novel Shape Complementarity Scoring Function For Protein-Protein Docking.
Proteins. 2003 May 15;51(3):397-408.
Abstract PDF
 
Hu, Z., Frith, M., Niu, T. & Weng, Z. (2003)
SeqVISTA: A Graphical Tool for Sequence Feature Visualization and Comparison
BMC Bioinformatics 4: 1
Abstract PDF
 
Kasif, S., Weng, Z. Derti, A., Beigel, R. & DeLisi, C. (2002)
A Computational Framework for Optimal Masking in the Synthesis of Oligonucleotide Microarrays.
Nucleic Acid Research 30(20): e106
Abstract PDF
 
Wong, J. Y., Weng, Z., Moll, S., Kim, S. & Brown, C. (2002)
Identification and validation of a novel cell-recognition site (KNEED) on the 8th type III domain of fibronectin.
Biomaterials 23: 3865-3870
Abstract PDF
 
Brown, C.T., Weng, Z., Zhang, H. & Wong, J.Y. (2002)
Mutational Analysis Verifies that "KNEED" Sequence of Fibronectin Participates in Cell-substrate Interactions.
Polym. Prep. 43(2): 754.
 
Frith, M.C., Hansen, U. & Weng, Z. (2002)
A Gibbs Sampling Algorithm to Detect Clustered Cis-elements.
Proceedings of the Third International Conference on Bioinformatics of Genome Regulation and Structure (1) 59-61
 
Anderson, R. & Weng, Z.
Bioinformatics.
Encyclopedia of Sciences 2002
PDF
 
J.D. Szustakowski and Z. Weng. (2002)
K2: Protein structure comparison and their statistical significance.
Evolutionary Computation in Bioinformatics.
Edited by G. Fogel and D. Corne, Morgan Kaufman.
Abstract PDF
 
Weng, Z. (2001)
Bioinformatics.
Macmillan's Biology
PDF
 
Betley JN, Frith MC, Graber JH, Choo S, Deshler JO. (2002)
A ubiquitous and conserved signal for RNA localization in chordates.
Curr Biol. 12(20):1756-61.
Abstract
 
Yu Zheng, Joseph D. Szustakowski, Lance Fortnow, Rich Roberts, Simon Kasif. (2002)
Computational identification of operons in microbial genomes.
Genome Research 12(8):1221-30
Abstract
 
Martin C. Frith, John L. Spouge, Ulla Hansen, Zhiping Weng. (2002)
Statistical significance of clusters of motifs represented by position specific scoring matrices in nucleotide sequences.
Nucleic Acids Research 30(14):3214-24
Abstract PDF
 
Chen, R. & Weng, Z. (2002)
Docking Unbound Proteins Using Shape Complementarity, Desolvation, and Electrostatics.
Proteins. Structure, Function, and Genetics. 47:281-294
Abstract PDF
 
Weng, Z. & DeLisi, C. (2002)
Protein Therapeutics: promises and challenges for the 21st century.
Trends in Biotechnology 20:29-35
Abstract PDF
 
Barbara L. Resendes, Nahid G. Robertson, Joseph D. Szustakowski, Robert J. Resendes, Zhiping Weng, and Cynthia C. Morton (2002)
Gene Discovery in the Auditory System: Characterization of Additional Cochlear-Expressed Sequences
Journal of the Association for Research in Otolaryngology 3(1):45-53
Abstract PDF
 
Haverty, PM., Weng, Z., Hsiao, L., Best, N., Auerbach, K., Jensen, RV., Gullans, SR. (2002)
HugeIndex: A Database of High Density Oligonucleotide Array Data from Normal Human Tissues
Nucleic Acids Research. 30(1): 214-217.
Abstract PDF
 
Frith, MC., Hansen, U., Weng, Z. (2001)
Detection of cis-element clusters in higher eukaryotic DNA
Bioinformatics 17(10):878-889
Abstract PDF
 
Hsiao, L.L., Dangond, F., Yoshida, T., Hong, R., Jensen, R.V., Misra, J., Dillon, W., Lee, K.F., Clark, K.E., Haverty, P., Weng, Z., Mutter, G.L., Frosch, M.P., Macdonald, M.E., Milford, E.L., Crum, C.P., Bueno, R., Pratt, R.E., Mahadevappa, M., Warrington, J.A., Stephanopoulos, G., Stephanopoulos, G., Gullans, S.R. (2001)
A Compendium of Gene Expression in Normal Human Tissues.
Physiological Genomics. 7: 97-104.
Abstract PDF
 
Lander ES, ... , Szustakowski J, ... ,et al. (2001)
Initial sequencing and analysis of the human genome.
Nature 409(6822):860-921
Abstract
 
Weng Z, DeLisi C
Amino acid substitutions: effects on protein stability.
Encyclopedia of Sciences
PDF
 
Szustakowski JD, Weng Z (2000)
Protein structure alignment using a genetic algorithm.
Proteins. 38(4):428-40
Abstract PDF
 
Chen, R.,, Xu, Y.Z., Wu, J.,Pu, Z., Jin, S.W., Liu, W.Y. & Xia, Z.X. (1999)
Purification and Characterization of Trichomaglin-A Novel Ribosomal-inactivating Protein with Abortificient Activity.
Biochem. Mol. Biol. Int. 47:185-93
Abstract
 
Esposito M, Venkatesh V, Otvos L, Weng Z, Vajda S, Banki K, Perl A (1999)
Human transaldolase and cross-reactive viral epitopes identified by autoantibodies of multiple sclerosis patients.
J. Immunol. 163(7):4027-4032
Abstract PDF
 
Anderson A, Weng Z (1999)
VRDD: Applying virtual reality visualization to protein docking and design.
J. Molecular Graphics & Modeling. 17(3-4):180-186, 217
Abstract PDF
 
Khanna R, Silins SL, Weng Z, Gatchell D, Burrows S, Cooper L (1999) Cytotoxic T cell recognition of allelic variants of HLA B35 bound to an Epstein-Barr virus epitope: influence of peptide conformation and TCR-peptide interaction.
Eur. J. Immunol. 29(5): 1587-1597
Abstract PDF
 
Skvorak AB, Weng Z, Yee AJ, Robertson NG, Morton CC (1999)
Human cochlear expressed sequence tags provide insight into cochlear gene expression and identify candidate genes for deafness.
Hum. Molec. Genet. 8(3): 439-452
Abstract PDF
 
Camacho C, Weng Z, Vajda S, DeLisi C (1999)
Free Energy Landscapes of Encounter Complexes in Protein-Protein Association.
BioPhys. J. 76(3): 1166-78
Abstract PDF
 
Wang, X.Q., Chen, R., Wang, Y.L., He, T.J. & Liu, F.C. (1998)
Theoretical Studies on Electrocompression of Electrodeposited Halid Monolayer on Au(111) Surface.
J. Phys. Chem. B102:7568-76
PDF
 
Weng Z, Gulukota K, Vaughn D, Bjorkman P, DeLisi C (1998)
Computational determination of the structure of Rat Fc bound to the neonatal Fc receptor.
J. Mol. Biol. 282(2): 217-225
Abstract PDF
 
Weng Z, DeLisi C (1998)
Toward a predictive understanding of molecular recognition.
Immuno. Rev. 163: 251-266
Abstract PDF
 
Zhang C, Kimura SR, Weng Z, Vajda S, Brower RC, DeLisi C (1998)
The waters of life.
J. Franklin Inst. 335B: 213-240.
PDF
 
DeLisi C, Cantor C, Weng Z (1997)
Hedgehogs, foxes, and a new science.
Nature Biotechnology 15(9): 819
Abstract PDF
 
Weng Z, DeLisi C, Vajda S. (1997)
Empirical free energy calculation: comparison to calorimetric data.
Protein Science 6(9): 1976-84.
Abstract PDF
 
Weng Z, Vajda S, DeLisi C. (1996)
Prediction of protein complexes using empirical free energy functions.
Protein Science 5(4): 614-26.
Abstract PDF
 
Vajda S, Weng Z, DeLisi C (1995)
Extracting hydrophobicity parameters from solute partition and protein mutation/unfolding experiments.
Protein Eng 8(11): 1081-92.
Abstract PDF
 
Vajda S, Weng Z, Rosenfeld R, DeLisi C. (1994)
Effect of conformational flexibility and solvation on receptor-ligand binding free energies.
Biochemistry 33(47): 13977-88.
Abstract PDF
 
 
     
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